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Treatment with Tramadol ER may be restricted to patients with renal or hepatic dysfunction (Ultram PI 2006). In multiple doses of tramadol 100 mg er, tramadol metabolite M1 vs. renal insufficiency in healthy volunteers (5080 ml / min creatinine) or (= 3050 ml / min) moderately moderate patients. Increased impact. In addition, M1 reduces exposure to about 50% of the metabolites, which is a lesion degradation compared to healthy subjects in mild to moderate patients. Tramadol should not be used in patients with severe renal impairment or severe hepatic dysfunction.
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Because of the risk and severity of serotonergic syndrome, the use of cetaloinergic citalopram should be considered in relation to other drugs such as tramadol. serotonin syndrome - rapid development of hyperthermia, hypertension, muscle spasms, stiffness, dysautonomia and the abnormal state of the state (eg delirium or coma), in exceptional cases, is death. Serotonergic syndrome may resemble malignant neuroleptic syndrome in its most complex form. Several cases of serotonin syndrome have been reported following administration of tramadol SSRIs. The combined use of SSRIs and tramadol is associated with an increased risk of heart attack. Creating a marketing report also means using tramadol for SSRI in some cases of seizures. Finally, citalopram is a weak inhibitor of CYP2D6. CYP2D6 analgesic tramadol activity resulting from the use of Desmetylotramadolu Original (M1) M1 drugs and metabolites and training activities.
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Tramadol is used for:
Treating moderate to moderately severe pain.
Tramadol is an analgesic. It works in certain areas of the brain and nervous system to decrease pain.

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How should I take Tramadol?
What happens if I miss a dose?
What happens if I overdose?
What should I avoid while taking Tramadol?
Tramadol side effects
Tramadol Dosing Information
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